Chemical
Pharmaceutical
Sci&Tech
Aptamer Drug Development Status and Pipeline
The development of therapeutic aptamers has evolved from a niche technology challenged by pharmacokinetic (PK) issues (stability and renal clearance) to a robust platform. While only two RNA aptamers are currently FDA-approved, the pipeline contains dozens...
Industry
Pharmaceutical
Regulation
Sci&Tech
PBPK Modeling -The Computational Engine Driving Modern Drug Safety
The pharmaceutical industry is undergoing a paradigm shift, moving towards New Approach Methodologies (NAMs) to reduce reliance on traditional animal models. At the forefront of this shift is Physiologically Based Pharmacokinetic (PBPK) modeling, a mechanism-driven computational approach...
Biotech
Industry
Pharmaceutical
Regulation
List of 2025 FDA New Drug Approvals
In 2025, FDA granted 44 novel drug approvals。This list summarizes the landmark novel therapeutic approvals, categorized by molecular modality and therapeutic area. Drug Name (Active Ingredient) Modality Company Indication Mechanism of Action (MoA) Key Highlights Journavx (Suzetrigine) Small Molecule Vertex...
Biotech
Pharmaceutical
Aptamer Drugs: The Next Generation of “Chemical Antibodies
Aptamers are a class of therapeutic molecules often called “chemical antibodies” because they perform the same function as traditional antibody drugs (binding to a target), but they are made from an entirely different material: short strands of nucleic...
Industry
Regulation
Sci&Tech
Comparative Summary of QSAR Platforms
This table provides a high-level comparison of the five key in silico tools based on their methodology, pros, cons, cost, and regulatory standing. Tool Primary Mechanism Key Advantage Key Disadvantage Regulatory Acceptance Cost/Access DEREK Nexus Rule-Based Expert System...
Biotech
Pharmaceutical
Sci&Tech
A Comprehensive Analysis of ADME Challenges for PROTACs
Proteolysis-targeting chimera (PROTAC) molecules have emerged as a revolutionary approach in drug discovery, offering the potential to selectively degrade target proteins. However, their design, characterized by a bivalent structure comprising a target protein-binding ligand (warhead), an E3...
Chemical
GLP
Pharmaceutical
Regulation
Sci&Tech
New Approach Methodologies for Chemical Safety Assessment
Within fields like toxicology and drug development, embracing New Approach Methodologies (NAMs) is no longer optional but crucial for professionals seeking to remain at the forefront of their disciplines. Understanding and applying these innovative, human-relevant techniques...
Molecule Digest
PopSci
A comparison of several common medical disinfectants
The concept of disinfection, while perhaps not explicitly articulated, has been practiced for centuries. However, the scientific understanding of microorganisms and their role in disease led to a more systematic approach to disinfection in the 19th...
Chemical
PopSci
Sci&Tech
A Personal View on the Business of AI Guided Chemical Synthesis
Observing the growing link between AI and chemical synthesis, the business potential is significant. AI promises faster, safer, cheaper, and more innovative chemical creation. However, widespread commercial use faces hurdles. A key business driver is AI’s...
Chemical
Pharmaceutical
Sci&Tech
Radiolysis in Pharmaceutical Development: Impact on Radionuclide Drugs and Mitigation Strategies
A Simple Explanation What is Radiolysis? Radiolysis is like a chemical breakdown caused by high-energy radiation . This radiation can split molecules apart . In water, this process creates very reactive particles. How Does it...
