Chemical

Chemical Pharmaceutical Sci&Tech

How bench scientist select a reactionsolvent (part-3/end)

When you are pushing a reaction toward a larger pilot-plant scale, or just trying to get enough material for the next stage of testing, you run into the gritty reality of process development: dealing with uncooperative,...

Chemical Pharmaceutical Sci&Tech

How bench scientist select a reactionsolvent (part-2)

Once you move past simple substitutions and start building carbon-carbon or carbon-nitrogen bonds, the solvent stops being a passive host and becomes a critical referee. In this phase of process chemistry, your choice of solvent is...

Chemical Pharmaceutical Sci&Tech

How bench scientist select a reactionsolvent (part-1)

You look up a prep in the literature, you see the authors used DCM, so you grab the DCM bottle without a second thought. If the reaction fails, you blame the catalyst, you question the purity...

Chemical Industry Regulation

Key notes of theOECD Guidance on Grouping of Chemicals

In the rapidly evolving landscape of product safety and drug development, the traditional “test everything” approach is becoming obsolete. Regulatory bodies, including the FDA and ECHA, are increasingly pivoting toward more efficient, humane, and scientifically...

Chemical Instrument PopSci

Why C18 Column is the Gold Standard of HPLC

If you’ve ever stepped into an analytical lab, you’ve likely seen a C18 column. Often called the “workhorse” of the laboratory, this single piece of technology handles nearly 80% of all high-performance liquid chromatography (HPLC) separations. I...

Chemical Pharmaceutical Sci&Tech

Aptamer Drug Development Status and Pipeline

The development of therapeutic aptamers has evolved from a niche technology challenged by pharmacokinetic (PK) issues (stability and renal clearance) to a robust platform. While only two RNA aptamers are currently FDA-approved, the pipeline contains dozens...

Chemical GLP Pharmaceutical Regulation Sci&Tech

New Approach Methodologies for Chemical Safety Assessment

Within fields like toxicology and drug development, embracing New Approach Methodologies (NAMs) is no longer optional but crucial for professionals seeking to remain at the forefront of their disciplines. Understanding and applying these innovative, human-relevant techniques...

Chemical PopSci Sci&Tech

A Personal View on the Business of AI Guided Chemical Synthesis

Observing the growing link between AI and chemical synthesis, the business potential is significant. AI promises faster, safer, cheaper, and more innovative chemical creation. However, widespread commercial use faces hurdles. A key business driver is AI’s...

Chemical Pharmaceutical Sci&Tech

Radiolysis in Pharmaceutical Development: Impact on Radionuclide Drugs and Mitigation Strategies

A Simple Explanation What is Radiolysis? Radiolysis is like a chemical breakdown caused by high-energy radiation . This radiation can split molecules apart . In water, this process creates very reactive particles. How Does it...

Chemical Industry Pharmaceutical Regulation

The Ames Test: Unraveling Mutagenic Potential

The Ames test, a cornerstone of genetic toxicology, serves as a crucial tool for identifying potential mutagens and carcinogens. Several regulatory guidelines govern the conduct and interpretation of Ames tests, including OECD Test Guideline 471: This guideline provides...