As the holiday is approaching, the list of approved drugs for this year can be finalized. Of the 32 drugs for 2022, there are 13 large molecules. The biological drugs keep the growing trend. Among these drugs, Krazati has cheered up the drug field quite a little bit, because the KRAS G12C was used to be believed as non-drugable target. Another drug, Pluvicto, encouraged the radiopharmaceutical development. Unsurprisingly, more radiopharmarceuticals will come to market in the coming years. Take a look at Elucirem, it is a MRI imaging reagents for detecting disease. It can easily convince you how radioactive medicines can be used as one-stone for two-birds.
I have covered the KRAS G12C target and Radiopharmaceuticals previously. Take a look if you are interested.
| # | Name | API | Modality | Indication |
| 32 | Krazati | adagrasib | small molecule | To treat KRAS G12C-mutated locally advanced or metastatic non-small cell lung cancer in adults who have received at least one prior systemic therapy |
| 31 | Rezlidhia | olutasidenib | small molecule | To treat adults with relapsed or refractory acute myeloid leukemia with a susceptible isocitrate dehydrogenase-1 (IDH1) mutation |
| 30 | Tzield | teplizumab-mzwv | large molecule | To delay the onset of stage 3 type 1 diabetes |
| 29 | Elahere | mirvetuximab soravtansine-gynx | large molecule | To treat patients with recurrent ovarian cancer that is resistant to platinum therapy |
| 28 | Tecvayli | teclistamab-cqyv | large molecule | To treat relapsed or refractory multiple myeloma among adults who have received at least four specific lines of therapy |
| 27 | Imjudo | tremelimumab | large molecule antibody | To treat unresectable hepatocellular carcinoma |
| 26 | Lytgobi | futibatinib | small molecule | To treat intrahepatic cholangiocarcinoma harboring fibroblast growth factor receptor 2 (FGFR2) gene fusions or other rearrangements |
| 25 | Relyvrio | sodium phenylbutyrate/taurursodiol | small molecule | To treat amyotrophic lateral sclerosis (ALS) |
| 24 | Omlonti | oomidenepag isopropyl ophthalmic solution | small molecule two drug combination | To reduce elevated intraocular pressure in patients with open‑angle glaucoma or ocular hypertension |
| 23 | Elucirem | gadopiclenol | small molecule gadolinium-based contrast agent | To detect and visualize lesions, together with MRI, with abnormal vascularity in the central nervous system and the body |
| 22 | Terlivaz | terlipressin | 12 amino acid peptide | To improve kidney function in adults with hepatorenal syndrome with rapid reduction in kidney function |
| 21 | Rolvedon | eflapegrastim | large molecule glycoprotein | To decrease the incidence of infection in patients with non-myeloid malignancies receiving myelosuppressive anti-cancer drugs associated with clinically significant incidence of febrile neutropenia |
| 20 | Sotyktu | deucravacitinib | small molecule | To treat moderate-to-severe plaque psoriasis |
| 19 | Daxxify | daxibotulinumtoixnA-lanm | large molecule | To treat moderate-to-severe glabellar lines associated with corrugator and/or procerus muscle activity |
| 18 | Spevigo | spesolimab-sbzo | large molecule | To treat generalized pustular psoriasis flares |
| 17 | Xenpozyme | Olipudase alfa | large molecule | To treat Acid Sphingomyelinase Deficiency |
| 16 | Amvuttra | vutrisiran | large molecule | To treat polyneuropathy of hereditary transthyretin-mediated amyloidosis |
| 15 | Vtama | tapinarof | small molecule | To treat plaque psoriasis |
| 14 | Mounjaro | tirzepatide | small molecule | To improve blood sugar control in diabetes, in addition to diet and exercise |
| 13 | Voquezna | vonoprazan, amoxicillin, and clarithromycin | small molecule | To treat Helicobacter pylori infection |
| 12 | Camzyos | mavacamten | small molecule | To treat certain classes of obstructive hypertrophic cardiomyopathy |
| 11 | Vivjoa | oteseconazole | small molecule | To reduce the incidence of recurrent vulvovaginal candidiasis (RVVC) in females with a history of RVVC who are not of reproductive potential |
| 10 | Pluvicto | lutetium (177Lu) vipivotide tetraxetan | small molecule | To treat prostate-specific membrane antigen-positive metastatic castration-resistant prostate cancer following other therapies |
| 9 | Opdualag | nivolumab and relatlimab-rmbw | large molecule | To treat unresectable or metastatic melanoma |
| 8 | Ztalmy | ganaxolone | small molecule | To treat seizures in cyclin-dependent kinase-like 5 deficiency disorder |
| 7 | Vonjo | pacritinib | small molecule | To treat intermediate or high-risk primary or secondary myelofibrosis in adults with low platelets |
| 6 | Pyrukynd | mitapivat | small molecule | To treat hemolytic anemia in pyruvate kinase deficiency |
| 5 | Enjaymo | sutimlimab-jome | large molecule | To decrease the need for red blood cell transfusion due to hemolysis in cold agglutinin disease |
| 4 | Vabysmo | faricimab-svoa | large molecule | To treat neovascular (wet) aged-related macular degeneration and diabetic macular edema |
| 3 | Kimmtrak | tebentafusp-tebn | large molecule | To treat unresectable or metastatic uveal melanoma |
| 2 | Cibinqo | abrocitinib | small molecule | To treat refractory, moderate-to-severe atopic dermatitis |
| 1 | Quviviq | daridorexant | small molecule | To treat insomnia |