Category: Sci&Tech
Pharmaceutical
Sci&Tech
Formulation Methods for Poorly Soluble Drugs
In the development of innovative drugs, poorly soluble candidate drugs of BCSII and BCSIV account for nearly 90%. And statistics show that about 40% of currently marketed drugs are poorly soluble compounds. Due to the poor oral absorption...
Pharmaceutical
Regulation
Sci&Tech
Implement New Approach Methodologies (NAMs) in Drug Development
The landscape of drug development is evolving, with a growing emphasis on reducing and replacing animal testing. New Approach Methodologies (NAMs) are at the forefront of this shift, offering innovative, non-animal methods to assess drug safety...
Pharmaceutical
Sci&Tech
Why Nav1.8 inhibitor is non-addictive pain killer
Journavx (VX-548, Suzetrigine) was approved in 2025 as the only new non-opoid painkiller in the past two decades. As we know it is a Nav1.8 inibitor, here we explain why Nav1.8 inhibitors won’t cause addiction(Disclaimer: based on the...
Industry
Pharmaceutical
Sci&Tech
Combination Drugs-Synergistic Therapy
A combination drug, or a fixed-dose combination (FDC), is a medication that includes two or more active ingredients combined into a single dosage form. Synergy occurs when drugs utilized in combination lead to a combined total effect...
Chemical
Pharmaceutical
Sci&Tech
what is drug-like properties
Drug-like properties, also known as druglikeness, are a crucial concept in the pharmaceutical world. They describe the inherent characteristics of a molecule that influence its potential for successful drug development. In 2000, Christopher A. Lipinski proposed...
Biotech
Pharmaceutical
Sci&Tech
Drug discovery: is target-based superior to phenotypic model?
In current pharmaceutical sciences, when we talk about innovative drug discovery, we should think of target-based drug discovery, which is to design synthetic drugs based on a target. Then, have we thought about how efficient this...
Sci&Tech
Basics of Radiopharmaceuticals
What is radiopharmaceutical? Radiopharmaceuticals include a group of radioactive agents used for either diagnostic or therapeutic interventions. Radiopharmaceutical therapy is defined by the delivery of radioactive atoms to disease-associated targets. But do not be confused with...
Sci&Tech
KRAS is no longer undruggable
A while ago, I wrote simply about the KRAS gene related research trend. It is official!! FDA grants FIRST accelerated approval to sotorasib for KRAS G12C mutated NSCLC. See the follow link for report by Fierce...
Industry
Sci&Tech
Program Overview: Small Business Innovation Research (SBIR) & Small Business Technology Transfer program (STTR)
When you come up a innovative idea that potentially can change the current tech market and enhance people’s life, why not chase your dream and bring your idea to market. Of course, you need funding to...
Industry
Sci&Tech
Positron emission tomography (PET) drugs, pipelines and market
Positron emission tomography (PET) drugs, pipelines and market Positron emission tomography (PET) is a nuclear medicine imaging technique that produces a three-dimensional image or picture of functional processes in the body. Drugs Used to Treat Positron...