Month: August 2026
Pharmaceutical
Sci&Tech
How to Solve Metabolic Stability Issues in Early Drug Discovery
You’ve designed a molecule with exceptional oral absorption and carefully tuned its physical chemistry to hit the optimal tissue distribution sweet spot. Yet, when you dose it in a rodent model, the drug’s systemic concentration plummets...
Chemical
Pharmaceutical
Sci&Tech
How bench scientist select a reactionsolvent (part-2)
Once you move past simple substitutions and start building carbon-carbon or carbon-nitrogen bonds, the solvent stops being a passive host and becomes a critical referee. In this phase of process chemistry, your choice of solvent is...
Pharmaceutical
Sci&Tech
How to Solve the Drug Distribution Issue in Early Discovery
You’ve optimized your lead molecule for flawless oral absorption and verified that it binds its target with nanomolar potency in biochemical assays. But when you dose it in vivo, the therapeutic effect is completely absent. You check...