Sci&Tech

Pharmaceutical Sci&Tech

Conventional or Microtracer method in human ADME

Notes from the Journal Article: Human Absorption, Distribution, Metabolism, and Excretion Studies: Conventional or Microtracer? Sean Xiaochun Zhu, Drug Metabolism and Disposition, DOI: https://doi.org/10.1016/j.dmd.2025.100067 This article provides a detailed review of a forthcoming publication in Drug Metabolism and Disposition...

Pharmaceutical Sci&Tech

Basics of Biomarker

What is a Biomarker? The term “biomarker” is composed of “biological” and “marker.” Different disciplines have slightly different definitions for biomarkers, but the general concept is consistent. The National Institutes of Health (NIH) in the...

Pharmaceutical Regulation Sci&Tech

ADME Testing: Your Drug’s Journey

Intro Why ADME? In Vitro vs. In Vivo ADME: The Breakdown For a deep dive into the details, you can continue reading for the next 3 minutes. The journey of a drug from the lab to the pharmacy...

Industry Sci&Tech

Basic Jargon in Technology Licensing

When licensing technology from a university or partner company, several key terms (jargon))are crucial to understand. As a scientists or engineers you should familiarize yourself with these terms which typically appear in a technology transfer agreement (TTA). Below are the core...

Pharmaceutical Sci&Tech

Formulation Methods for Poorly Soluble Drugs

In the development of innovative drugs, poorly soluble candidate drugs of BCSII and BCSIV account for nearly 90%. And statistics show that about 40% of currently marketed drugs are poorly soluble compounds. Due to the poor oral absorption...

Pharmaceutical Regulation Sci&Tech

Implement New Approach Methodologies (NAMs) in Drug Development

The landscape of drug development is evolving, with a growing emphasis on reducing and replacing animal testing. New Approach Methodologies (NAMs) are at the forefront of this shift, offering innovative, non-animal methods to assess drug safety...

Pharmaceutical Sci&Tech

Why Nav1.8 inhibitor is non-addictive pain killer

Journavx (VX-548, Suzetrigine) was approved in 2025 as the only new non-opoid painkiller in the past two decades. As we know it is a Nav1.8 inibitor, here we explain why Nav1.8 inhibitors won’t cause addiction(Disclaimer: based on the...

Industry Pharmaceutical Sci&Tech

Combination Drugs-Synergistic Therapy

A combination drug, or a fixed-dose combination (FDC), is a medication that includes two or more active ingredients combined into a single dosage form. Synergy occurs when drugs utilized in combination lead to a combined total effect...

Chemical Pharmaceutical Sci&Tech

what is drug-like properties

Drug-like properties, also known as druglikeness, are a crucial concept in the pharmaceutical world. They describe the inherent characteristics of a molecule that influence its potential for successful drug development. In 2000, Christopher A. Lipinski proposed...

Biotech Pharmaceutical Sci&Tech

Drug discovery: is target-based superior to phenotypic model?

In current pharmaceutical sciences, when we talk about innovative drug discovery, we should think of target-based drug discovery, which is to design synthetic drugs based on a target. Then, have we thought about how efficient this...