Biotech
Pharmaceutical
Sci&Tech
A Comprehensive Analysis of ADME Challenges for PROTACs
Proteolysis-targeting chimera (PROTAC) molecules have emerged as a revolutionary approach in drug discovery, offering the potential to selectively degrade target proteins. However, their design, characterized by a bivalent structure comprising a target protein-binding ligand (warhead), an E3...
Chemical
GLP
Pharmaceutical
Regulation
Sci&Tech
New Approach Methodologies for Chemical Safety Assessment
Within fields like toxicology and drug development, embracing New Approach Methodologies (NAMs) is no longer optional but crucial for professionals seeking to remain at the forefront of their disciplines. Understanding and applying these innovative, human-relevant techniques...
Molecule Digest
PopSci
A comparison of several common medical disinfectants
The concept of disinfection, while perhaps not explicitly articulated, has been practiced for centuries. However, the scientific understanding of microorganisms and their role in disease led to a more systematic approach to disinfection in the 19th...
Chemical
PopSci
Sci&Tech
A Personal View on the Business of AI Guided Chemical Synthesis
Observing the growing link between AI and chemical synthesis, the business potential is significant. AI promises faster, safer, cheaper, and more innovative chemical creation. However, widespread commercial use faces hurdles. A key business driver is AI’s...
Chemical
Pharmaceutical
Sci&Tech
Radiolysis in Pharmaceutical Development: Impact on Radionuclide Drugs and Mitigation Strategies
A Simple Explanation What is Radiolysis? Radiolysis is like a chemical breakdown caused by high-energy radiation . This radiation can split molecules apart . In water, this process creates very reactive particles. How Does it...
Pharmaceutical
Sci&Tech
Conventional or Microtracer method in human ADME
Notes from the Journal Article: Human Absorption, Distribution, Metabolism, and Excretion Studies: Conventional or Microtracer? Sean Xiaochun Zhu, Drug Metabolism and Disposition, DOI: https://doi.org/10.1016/j.dmd.2025.100067 This article provides a detailed review of a forthcoming publication in Drug Metabolism and Disposition...
Pharmaceutical
Sci&Tech
Basics of Biomarker
What is a Biomarker? The term “biomarker” is composed of “biological” and “marker.” Different disciplines have slightly different definitions for biomarkers, but the general concept is consistent. The National Institutes of Health (NIH) in the...
Chemical
Industry
Pharmaceutical
Regulation
The Ames Test: Unraveling Mutagenic Potential
The Ames test, a cornerstone of genetic toxicology, serves as a crucial tool for identifying potential mutagens and carcinogens. Several regulatory guidelines govern the conduct and interpretation of Ames tests, including OECD Test Guideline 471: This guideline provides...
Pharmaceutical
Regulation
Sci&Tech
ADME Testing: Your Drug’s Journey
Intro Why ADME? In Vitro vs. In Vivo ADME: The Breakdown For a deep dive into the details, you can continue reading for the next 3 minutes. The journey of a drug from the lab to the pharmacy...
Biotech
Industry
The foundations of a biotech startup
A biotech startup is a complex endeavor, requiring a strong foundation in science, business, and regulatory affairs.Here are the key elements: 1. A Strong Scientific Idea or Technology: Novelty: The technology should be novel and have the potential...